Venezia Santa Lucia is the only railway station on the island of Venice, surrounded by many ancient buildings. The station is the central station in northeastern Italy. It is a destination located on the northern edge of the historic city of Centro storico in Venice. The station is one of the two most important railway stations in Venice; the other is the Mestre in Venice, located at the main line of the Mestre region of Venice.

Located in the Cannaregio district, the station is the northernmost of the six historic districts in Venice's historic city. It is located on the northernmost island, near the western end of the Grand Canal. The bridge over the Grand Canal connects the square in front of the station to the Santa Croce. The station was built in 1860 and the Santa Lucia Church was demolished for this purpose. The station was then completed, named after the church. The train station offers high-speed trains and local train services. The train station is connected to the rest of Venice via the Vaporetto (public water bus) or a private water taxi. The nearby Roman Forum is the starting point for all car services and taxis.

The entire station has Trenitalia and Italo self-service ticket vending machines, easy to use, with touch screen and English facilities. The Trenitalia ticket office is located in the southwest corner of the station, right next to the lobby. Walk into the hall to the outside hall, then turn left and you will be there. There are ATMs in every place.

Trenitalia has a first-class lounge (Freccia Club with free WiFi) in the inner hall near the 13th platform, but only for first class passengers or for certain Trenitalia membership cards. The Casa Italo small lounge (near station 14) offers seating and free WiFi for all Italo passengers, but there is no Club class Italo lounge in Venice. The best place to wait for the train is the upstairs lounge area above the food court near the external square.