Station Brussel-Zuid/Midi (IATA: ZYR) is the largest railway station in Brussels, Belgium. There is a subway station at the train station. Every day, 1000 trains pass through the two stations in Brussels.

The station has 22 months of trains, including the Eurostar, Hercules high-speed train, TGV, ICE and so on. This station is the terminus of the HSL 1 railway route. To the east of the train station is Fonsny / Fonsnylaan Avenue and to the west is Rue de France / Frankrijkstraat. The subway station was named Gare du Midi / Zuidstation and was opened in 1988. Since 1993, the station has also provided premetro (underground tram) services on different platforms. The shuttle service to Brussels South Charleroi Airport departs from the stop at Rue de France / Frankrijkstraat.

The tallest building in Belgium, the South Tower, is located in front of the main exit of the station (Fonsny / Fonsnylaan Avenue and the intersection of Rue Couverte / Overdektestraat), next to the Pension Service Centre (FPS).