Heidelberg Hauptbahnhof is the main train station in Heidelberg, Germany. In 2005, it was used by approximately 42,000 passengers per day and is one of the largest passenger stations in Baden-Württemberg. The station is the second-class station of the German Railway.

It was built in 1840. The current station was built in 1955 and is considered to be the most beautiful and architecturally interesting building of the German Federal Railways. It was listed as a historical monument in Baden-Württemberg in 1972. The station is located in Willy-Brandt-Platz, about two kilometres west of downtown Heidelberg.

The main train station in Heidelberg is not too far from the old town and has convenient transportation. There are facilities such as catering, supermarkets, and storage boxes in the station. Heidelberg is not a transportation hub. There are not many ICE express trains passing through Heidelberg, mainly IC fast trains and regional slow trains. Heidelberg train station also has frequent regional S-Bahn, which provides easy access to the surrounding towns.