Mendrisio railway station is a railway station in the Swiss canton of Ticino and municipality of Mendrisio. The station is on the Swiss Federal Railways Gotthard railway, between Lugano and Chiasso, and is also the junction for the Mendrisio–Stabio railway, currently only used for freight traffic, but being rebuilt as an international connection to Varese.

The station is served by trains on line S10 of the Treni Regionali Ticino Lombardia (TILO), which operate every half-hour between Bellinzona, Lugano and Chiasso, with some trains extending northwards to Airolo and southwards to Milan. It is also served, on an irregular basis, by Swiss Federal Railways long distance trains between northern Switzerland and Chiasso.